CarCareTruth Score
Decent, but it's tough on the environment.
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Prices may varyThe manufacturer's Safety Data Sheet classifies this product with one or more GHS Category 1 health hazards — the most severe tier. The hazard statements in quotes below are the verbatim GHS language from the SDS, as required by OSHA's Hazard Communication Standard. The line under each statement translates the GHS classification into plain language.
GHS Category 1 carcinogenicity — classified as suspected of causing cancer with repeated or prolonged exposure.
GHS Category 1 aspiration toxicity — thin, oily liquids can slip into the lungs if swallowed, causing chemical pneumonia.
If swallowed, inhaled, or splashed in eyes:
Call Poison Control immediately at 1-800-222-1222 (US, 24/7, free) and have the product container with you. Poison Control's standing guidance is to not induce vomiting after chemical exposure; they will direct first-aid steps based on the specific product.
About this product's hazards. This product's Safety Data Sheet uses signal word danger. Read the manufacturer's SDS and follow all safety instructions before use. CarCareTruth ratings translate the manufacturer's safety sheet. They do not replace the SDS or substitute for a hazard assessment specific to your task.
This product ranks #8 of 16 in Fuel Injector Cleaner.Three above it ↓
Last reviewed July 2, 2026
TL;DR PEA formula: polyetheramine, the most independently studied injector detergent chemistry, confirmed from the US SDS. Health score 4.5 (Serious Hazard): H350 carcinogen classification (trace carcinogen ingredient), Prop 65 warning on the product listing. Do not induce vomiting if ingested; seek medical attention.
Gumout Regane High Mileage uses polyetheramine (PEA), confirmed from the US SDS at 25-<50% by weight, an unusually transparent disclosure for this category. PEA is the class with the most research on injector and intake valve deposit removal. Positioned for vehicles with 75,000+ miles; covers GDI and port-injection engines. Community evidence is positive but moderate: well-reviewed by owners, no independent test data. Treatment protocol: one bottle per tank every 3,000 miles.
Best for higher-mileage owners running non-Top Tier gasoline who want a confirmed-PEA maintenance treatment for GDI and port-injection engines. Skip it if you consistently run Top Tier certified fuel; the OEM detergent package already does this job. Skip it for severe rough idle or hesitation; professional ultrasonic injector cleaning is the right call at that point.
SDS §2 is DANGER: H350 (carcinogen Cat 1B) and H304 (aspiration toxicant: the hazard is swallowed liquid entering the lungs, not contact or inhalation at the pour). No skin, eye, or respiratory H-codes at mixture level. Do not induce vomiting if ingested; seek medical attention. The product combusts in the engine; exhaust byproducts are the environmental endpoint. The product listing carries a Prop 65 warning; SDS §15 names a trace carcinogen ingredient as the basis.
The active detergent is PEA (polyetheramine), confirmed directly from the US SDS at a concentration of 25 to under 50 percent by weight. That is an unusually transparent disclosure for this category, where most brands hide the active behind a 'proprietary detergent package.' PEA is the detergent class with the most independent research behind injector and intake-valve deposit removal, the same chemistry family used in Top Tier gasoline additive packages.
Yes. The brand product page lists both GDI/direct fuel injectors and port/indirect injectors in its coverage, so it targets direct-injection carbon buildup as well as port-injector fouling. It is stated safe for turbocharged and supercharged engines, and compatible with ethanol blends up to E15. No documented fuel-system compatibility failures were found in community evidence.
The label protocol is one 6 fl oz bottle added to a nearly empty tank, then filled with up to 21 gallons of gasoline, repeated every 3,000 miles. It is positioned as an ongoing maintenance treatment for higher-mileage vehicles rather than a one-time intensive flush, and the concentration matches that maintenance use case. It works with all unleaded, oxygenated, and reformulated gasolines.
The product listing shows a California Proposition 65 warning, and the SDS names a trace carcinogen solvent component (present at under half a percent) as the basis. The SDS §2 mixture classification is DANGER for H350 (may cause cancer) and H304 (aspiration hazard if swallowed). This drives the CCT health score of 4.5, in the Serious Hazard band. Do not induce vomiting if ingested; seek medical attention.
If you consistently run Top Tier certified gasoline, the OEM detergent package already handles injector deposits, so a maintenance additive adds little. Its value is for owners running non-Top-Tier fuel who want a confirmed-PEA maintenance treatment for a higher-mileage GDI or port-injection engine. Pricing is competitive for a confirmed-PEA product, though the 6 oz treatment size is smaller than some 20 oz category rivals.
Marketing copy from Gumout, via Amazon. Not editorial.
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