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2-Methoxypropanol

  • Glycol ether solvents
  • CAS 1589-47-5
  • IUPAC: 2-Methoxy-1-propanol

Classified as Reproductive Toxin Category 1B (H360 — may damage fertility or the unborn child) in EU REACH / GHS. At 0.1–1% in consumer cleaning formulas, exposure is far below occupational thresholds, but the reproductive toxin classification is a legitimate concern for regular users — especially pregnant individuals. WHMIS ITSL: 660 µg/m³ (inhalation). No carcinogenicity or sensitization classification. Skin and eye irritation at high concentrations. Different compound from 1-methoxy-2-propanol (PGME, CAS 107-98-2), which has a more established safety profile and is CARB-exempt; 2-methoxypropanol (CAS 1589-47-5) is the 2- isomer and is not CARB-exempt.

2-Methoxypropanol (CAS 1589-47-5) is a glycol ether co-solvent used in water-based cleaning systems to improve surfactant coupling and solution stability. It should not be confused with propylene glycol monomethyl ether (PGME, 1-methoxy-2-propanol, CAS 107-98-2), which is a different structural isomer with a more benign regulatory profile. The primary health concern is reproductive toxicity — 2-methoxypropanol is classified H360 (Repr. 1B) under EU REACH / GHS, meaning it may damage fertility or the unborn child. At concentrations below 1% in consumer formulas, exposure during normal use is expected to be below the reproductive no-effect level, but the classification reflects a real hazard mechanism (glycol ethers in this family can be metabolized to alkoxypropionic acids that interfere with spermatogenesis and embryo development). Pregnant individuals should avoid handling products containing this ingredient.

Health & environment profile

VOC
yes
Prop 65 listed
no
Asthmagen
no
EPA Safer Choice
no
Aquatic toxicity
no
Biodegradable
yes
Bioaccumulative
no
Persistent
no
Ozone depleting
no
Microplastic
no
PFAS
no
Env. score
4/5
Purpose: Coalescing co-solvent and coupling agent in water-based cleaning formulas; improves surfactant system stability

1 product contain this

Health summaries are editorial — we synthesize from SDSs, peer-reviewed sources, and regulatory listings. Not medical advice.