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3-Trimethoxysilylpropane-1-thiol

  • Ceramic (SiO₂)
  • CAS 4420-74-0
  • IUPAC: 3-(Trimethoxysilyl)propane-1-thiol

3-Trimethoxysilylpropane-1-thiol (CAS 4420-74-0) appears in 1 of the 1,812 car-care products CarCareTruth tracks (as of June 2026).

Classified Acute Tox. 4 oral (H302, LD50 741 mg/kg rat), Skin Sens. 1 (H317 — may cause an allergic skin reaction), Aquatic Chronic 2 (H411). Thiol functional group has a characteristic odor at trace levels. Skin sensitization is the meaningful repeat-exposure concern; gloves matter during application.

3-Trimethoxysilylpropane-1-thiol (CAS 4420-74-0) is a mercaptosilane coupling agent — a small molecule with two reactive ends, a thiol on one side and a trimethoxysilyl group on the other. In windshield coatings it functions as a co-crosslinker alongside an alkylsilane primary film-former: the trimethoxysilyl end hydrolyzes and bonds to the glass; the thiol end participates in network-forming chemistry with adjacent silanes and any disulfide-active components in the formula.

Hazard-wise, the SDS classifies it as a skin sensitizer (H317) — repeat skin contact during application can produce an allergic dermatitis response in susceptible individuals, which is why SDS §8 specifies gloves rather than treating skin protection as optional. It is also classified as Aquatic Chronic 2 (H411). At 1–3% in the finished product, the contribution to the mixture-level classification is suppressed under CLP additivity rules — FlyBy Forte's overall mixture classification carries H317 but not H411. The thiol odor is detectable at trace levels and is often the first cue that a coating chemistry includes a mercaptosilane.

Health & environment profile

VOC
no
Prop 65 listed
no
Asthmagen
no
EPA Safer Choice
no
Aquatic toxicity
yes
Biodegradable
no
Bioaccumulative
no
Persistent
no
Ozone depleting
no
Microplastic
no
PFAS
no
Env. score
4/5
Purpose: Mercaptosilane coupling agent used in advanced windshield-coating chemistries. The thiol terminal binds to certain inorganic surfaces and crosslinks with disulfide and silane partners; the trimethoxysilyl head hydrolyzes to bond with silica-rich substrates like glass.

Common questions about 3-Trimethoxysilylpropane-1-thiol

What is 3-Trimethoxysilylpropane-1-thiol used for in car care?
Mercaptosilane coupling agent used in advanced windshield-coating chemistries. The thiol terminal binds to certain inorganic surfaces and crosslinks with disulfide and silane partners; the trimethoxysilyl head hydrolyzes to bond with silica-rich substrates like glass.
Is 3-Trimethoxysilylpropane-1-thiol a VOC?
No. 3-Trimethoxysilylpropane-1-thiol is not classified as a volatile organic compound (VOC).
Is 3-Trimethoxysilylpropane-1-thiol on California's Proposition 65 list?
No. 3-Trimethoxysilylpropane-1-thiol is not on California's Proposition 65 list.

1 product contain this

Related

Health and environment notes translate the manufacturer Safety Data Sheet, the GHS classification, and authoritative regulatory listings (California Prop 65, EPA). Not medical advice. They describe the ingredient itself; whether a hazard applies to a finished product depends on its concentration and how it's used.