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2,2,3,3-Tetrafluoropropan-1-ol

  • Other solvents
  • CAS 76-37-9
  • IUPAC: 2,2,3,3-Tetrafluoropropan-1-ol

2,2,3,3-Tetrafluoropropan-1-ol (CAS 76-37-9) appears in 1 of the 1,812 car-care products CarCareTruth tracks (as of June 2026). It is a PFAS chemical and classified as a VOC.

Classified Flam. Liq. 3 (H226) and Acute Tox. 4 inhalation (H332) with ATE 11 mg/L for vapors. Harmful if inhaled at concentration. Used as the dominant carrier (80–85%) in CarPro FlyBy Forte; ventilation matters during application because the inhalation hazard is meaningful, not boilerplate. Not classified as a skin or eye irritant in the available SDS data.

2,2,3,3-Tetrafluoropropan-1-ol (CAS 76-37-9) is a fluorinated alcohol used as the carrier solvent in CarPro FlyBy Forte at 80–85% by weight. It serves the same volatile-carrier role that ethanol plays in FlyBy30 — disperse the silane active, flash off during cure, leave the bonded silane network on the glass.

The fluorine substitution sets it apart from ordinary alcohol carriers in two ways. First, under the OECD 2021 PFAS structural definition — "any substance containing at least one fully fluorinated methyl or methylene carbon atom" — the –CF2–CF2– backbone qualifies it as PFAS. It is a short-chain fluorinated solvent, not a long-chain perfluoroalkyl surfactant like PFOA, so the bioaccumulation and persistence profile is materially milder than the perfluorinated C8 chains found in classical fluoroalkylsilane coatings. But the C–F bonds still resist standard hydrolysis and microbial degradation. Second, the SDS classifies it as Acute Tox. 4 inhalation (H332) with a vapor ATE of 11 mg/L — the inhalation hazard for FlyBy Forte during application is driven primarily by this carrier, not by the silane actives at 1–3%.

Health & environment profile

VOC
yes
Prop 65 listed
no
Asthmagen
no
EPA Safer Choice
no
Aquatic toxicity
no
Biodegradable
no
Bioaccumulative
no
Persistent
yes
Ozone depleting
no
Microplastic
no
PFAS
yes
Env. score
3/5
Purpose: Fluorinated alcohol carrier solvent used in fluoroalkylsilane and silane-thiol windshield-coating systems. Volatile fluorinated co-solvent that disperses the silane active and evaporates during cure, leaving the bonded silane network on the glass.

Common questions about 2,2,3,3-Tetrafluoropropan-1-ol

What is 2,2,3,3-Tetrafluoropropan-1-ol used for in car care?
Fluorinated alcohol carrier solvent used in fluoroalkylsilane and silane-thiol windshield-coating systems. Volatile fluorinated co-solvent that disperses the silane active and evaporates during cure, leaving the bonded silane network on the glass.
Is 2,2,3,3-Tetrafluoropropan-1-ol a VOC?
Yes. 2,2,3,3-Tetrafluoropropan-1-ol is classified as a volatile organic compound (VOC).
Is 2,2,3,3-Tetrafluoropropan-1-ol on California's Proposition 65 list?
No. 2,2,3,3-Tetrafluoropropan-1-ol is not on California's Proposition 65 list.
Is 2,2,3,3-Tetrafluoropropan-1-ol a PFAS chemical?
Yes. 2,2,3,3-Tetrafluoropropan-1-ol is a per- or polyfluoroalkyl substance (PFAS).

1 product contain this

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Health and environment notes translate the manufacturer Safety Data Sheet, the GHS classification, and authoritative regulatory listings (California Prop 65, EPA). Not medical advice. They describe the ingredient itself; whether a hazard applies to a finished product depends on its concentration and how it's used.