Priced as of May 17, 2026
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Prices may varyFrom the Safety Data Sheet
Full SDS ↗ (rev. 2022-11-03)GHS hazard codes are quoted from the manufacturer’s Safety Data Sheet. PPE tiers below translate those codes and the listed ingredient chemistry; they are not CarCareTruth recommendations.
EyesSituationalMfr. SDS §8Skin—No PPE in published sourcesLungs—No PPE in published sourcesVentilation—No PPE in published sourcesShow details for all categories ▾Hide details ▴
From the manufacturer’s Safety Data Sheet, Section 8
“SDS §11 notes direct eye contact 'may produce transient discomfort characterised by tearing or conjunctival redness.' Label states 'CAUTION: MAY CAUSE EYE IRRITATION.' No H319 or H318 in SDS §2 (classified Not Applicable). Splash risk limited to fill operation; the small DEF port reduces exposure.”
— Prestone
CarCareTruth publishes the cited sources verbatim and does not advise what action a user should take. Consult the full SDS before use.
No PPE specified in published sources for skin. Absence does not imply “not needed” — consult the full Safety Data Sheet.
No PPE specified in published sources for lungs. Absence does not imply “not needed” — consult the full Safety Data Sheet.
No PPE specified in published sources for ventilation. Absence does not imply “not needed” — consult the full Safety Data Sheet.
PPE tiers translate the manufacturer’s SDS and U.S. regulatory standards. Not professional safety advice. How we report safety.
CarCareTruth's Analysis
Last reviewed May 18, 2026
TL;DR API DEF Certified with the ISO 22241 seal confirmed on the label — compliance is third-party audited, not just brand-stated. Standard 2.5-gallon polyethylene jug with a functional pour spout; no anti-crystallization nozzle. Widely available through AutoZone, Walmart, and Amazon.
What it is and how it performs
Prestone Command DEF is 32.5% automotive-grade urea in deionized water per ISO 22241. It carries the API Diesel Exhaust Fluid Certification Program seal — subject to the API's audit and spot-testing program, not brand-only compliance claims. No separately published third-party laboratory test results were found. The 2.5-gallon polyethylene jug uses a standard pour-spout compatible with most DEF fill funnels. Compatible with AdBlue and other DEF products. A 6-pack variant (B00PLLRLKK) is available for owners who prefer to stock up.
Who should buy this — and who should skip it
Good for diesel pickup owners (RAM, Ford Power Stroke, GM Duramax) who prefer a nationally known brand with confirmed API certification. The 2.5-gallon format suits light-use diesel passenger car owners who refill infrequently. High-mileage fleet owners will find better per-gallon value in the 6-pack. Skip if your vehicle does not have an SCR system — DEF is exclusively for diesel engines with selective catalytic reduction, not gasoline or non-SCR diesel vehicles.
Safety and environmental impact
The SDS (Recochem Inc., November 2022) classifies this product as "Not Applicable" under GHS — no signal word, no pictograms, no hazard codes. Direct eye splash may cause mild transient discomfort per SDS §11; no skin or respiratory codes are assigned. Urea-water is biodegradable with low persistence and carries no GHS aquatic toxicity classification.
Frequently asked questions
Is Prestone Command DEF API certified?▾
Yes — the API Diesel Exhaust Fluid Certification seal is visible on the label, and the Amazon listing states the product is certified to meet all API and ISO 22241 requirements. The API certification program includes spot-testing of retail samples.
What engines is Prestone Command DEF compatible with?▾
Prestone Command DEF is formulated for all SCR (Selective Catalytic Reduction)-equipped diesel engines. It is not for use in gasoline, hybrid-electric, or diesel engines without SCR systems — DEF is only consumed by vehicles with SCR emissions control technology.
Can I use Prestone Command DEF in my diesel pickup truck?▾
Yes, if your diesel pickup has an SCR system — which includes virtually all modern diesel light-duty trucks from 2010 onward (RAM, Ford Power Stroke, GM Duramax). Check your owner's manual for the DEF fill port location and refill interval.
Is Prestone Command DEF biodegradable?▾
Urea-water solutions are biodegradable — the SDS lists urea persistence in water and soil as low. The product carries no GHS aquatic toxicity classification.
How often do I need to refill DEF?▾
Most diesel passenger vehicles consume DEF at roughly 2–3% of diesel fuel usage, requiring a refill every 3,000–6,000 miles. High-mileage diesel pickup owners may refill more frequently. The vehicle's instrument panel will indicate when the DEF level is low.
From the manufacturer
Marketing copy from Prestone, via Amazon. Not editorial.
- •Formulated to work with all SCR-equipped diesel engines
- •Safe, easy-to-handle, nontoxic solution of 67.5% water and 32.5% automotive grade urea
- •Certified to meet all API & ISO 22241 requirements
- •Compatible with AdBlue and other DEF products
- •DEF is a consumable and essential fluid for maintaining SCR-equipped modern diesel engines
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Manufacturer images
Manufacturer specifications
- Brand
- Prestone
- Liquid Volume
- 320 Fluid Ounces
- Package Information
- plastic
- Vehicle Service Type
- SCR-equipped diesel engines
- UPC
- 797496878007
- Container Type
- plastic
- Compatible with Vehicle Type
- SCR-equipped diesel engines
- Automotive Fit Type
- Universal Fit
- Brand Name
- Prestone
- Manufacturer Part Number
- HD1001
- Global Trade Identification Number
- 00797496878007
- Manufacturer
- Prestone
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